{"id":2157,"date":"2019-10-29T09:38:00","date_gmt":"2019-10-29T01:38:00","guid":{"rendered":"https:\/\/tcr.cph.ntu.edu.31app.tw\/?p=2157"},"modified":"2022-01-22T09:51:52","modified_gmt":"2022-01-22T01:51:52","slug":"%e7%99%8c%e7%99%bb%e7%ac%ac108009%e8%99%9f%e9%80%9a%e7%9f%a5%e6%96%87-%e5%9b%a0%e6%87%89%e7%99%8c%e7%97%87%e7%99%bb%e8%a8%98%e5%af%a6%e5%8b%99%e4%bd%9c%e6%a5%ad%e4%b9%8b%e9%9c%80%e6%b1%82%ef%bc%8c","status":"publish","type":"post","link":"https:\/\/twcr.tw\/?p=2157","title":{"rendered":"[\u764c\u767b\u7b2c108009\u865f\u901a\u77e5\u6587] \u56e0\u61c9\u764c\u75c7\u767b\u8a18\u5be6\u52d9\u4f5c\u696d\u4e4b\u9700\u6c42\uff0c\u8acb \u8cb4\u9662\u4f9d\u8aaa\u660e\u6bb5\u8fa6\u7406"},"content":{"rendered":"<p>\u4e00\u3001 \u672c\u6848\u4fc2\u4f9d\u885b\u751f\u798f\u5229\u90e8\u570b\u6c11\u5065\u5eb7\u7f72\u59d4\u8a17\u300c\u53f0\u7063\u764c\u75c7\u767b\u8a18\u5de5\u4f5c\u8a08\u756b\u300d\u8fa6\u7406\u3002<\/p>\n<p>\u4e8c\u3001 \u570b\u6c11\u5065\u5eb7\u7f72\u696d\u65bc10\u670824\u65e5(\u570b\u5065\u764c\u5b57\u7b2c1080301415)\u767c\u6587\u516c\u544a107\u5e74\u764c\u75c7\u500b\u6848\u63d0\u9192\u540d\u55ae\u76f8\u95dc\u4f5c\u696d\u6642\u7a0b\uff0c\u8acb\u4f9d\u64da\u516c\u6587\u5167\u5bb9\u9032\u884c\u7533\u5831\uff1b\u53e6\u8acb\u81f3\u300e\u764c\u75c7\u7be9\u6aa2\u8207\u8ffd\u8e64\u7ba1\u7406\u8cc7\u8a0a\u6574\u5408\u7cfb\u7d71\u300f\u4e0b\u8f0910\u670828\u65e5\u6700\u65b0\u516c\u5e03\u4e4b\u63d0\u9192\u540d\u55ae\uff0c\u4e26\u65bc108\u5e7412\u670831\u65e5\u6cd5\u5b9a\u622a\u6b62\u65e5\u671f\u524d\u5b8c\u6210\u7533\u5831\u3002<\/p>\n<p>\u4e09\u3001 \u6709\u95dcSquamous cell carcinoma, HPV-positive or HPV-negative\u300c\u7d44\u7e54\u578b\u614b\u300d\u7de8\u78bc8085\u62168086\u8005\uff1a<br \/>\n<strong>\u56e0<\/strong><strong>HPV-positive<\/strong><strong>\u4e0d\u76f8\u7576\u65bc<\/strong><strong>HPV-mediated (p16+)<\/strong><strong>\uff0c\u6545<u>\u50c5<\/u>\u57f7\u884c<\/strong><strong><u>p16<\/u><\/strong><strong><u>\u6aa2\u6e2c<\/u><\/strong><strong>\uff0c\u8acb\u52ff\u7de8\u78bc\u70ba<\/strong><strong>8085<\/strong><strong>\u6216<\/strong><strong>8086<\/strong><strong>\u3002<\/strong>HPV-positive\u662f\u6307HPV\u75c5\u6bd2\u611f\u67d3\u70ba\u967d\u6027\uff0c\u8207p16\u86cb\u767d\u6709\u904e\u5ea6\u8868\u73fe(p16 +)\u4e0d\u540c\uff1b\u4e14HPV\u611f\u67d3\u6aa2\u6e2c\u662f\u4ee5\u539f\u4f4d\u96dc\u4ea4\u6280\u8853(In Situ Hybridization, ISH)\u6216\u805a\u5408\u9176\u9023\u9396\u53cd\u61c9(Polymerase Chain Reaction, PCR)\u7b49\u65b9\u6cd5\u4f86\u6aa2\u6e2cHPV DNA\u75c5\u6bd2\u91cf\uff0c\u800cp16\u86cb\u767d\u8868\u73fe(HPV\u7684\u66ff\u4ee3\u6a19\u8a18)\u7684\u6aa2\u6e2c\uff0c\u50c5\u63a1\u7528\u514d\u75ab\u7d44\u7e54\u5316\u5b78\u67d3\u8272\u6280\u8853(Immunohistochemistry, IHC)\u3002\u6545HPV-positive\u5fc5\u9808\u901a\u904e\u75c5\u6bd2\u6aa2\u6e2c\u70ba\u967d\u6027\uff0c\u624d\u80fd\u5c07\u7d44\u7e54\u578b\u614b\u7de8\u78bc\u70ba8085 (\u53c3\u8003\u8cc7\u6599\uff1a2018 Solid Tumor rules\u7b2c105\u9801)\u3002\u96d6\u7136p16\u967d\u6027\u7684\u8868\u73fe\u8207\u982d\u9838\u90e8\u9c57\u72c0\u7d30\u80de\u764c(HNSCC)\u4e2d\u7684HPV\u611f\u67d3\u6709\u9ad8\u5ea6\u76f8\u95dc\uff0c\u4f46p16\u967d\u6027\u4e0d\u50c5\u9650\u65bcHPV\u967d\u6027\u816b\u7624\uff0c\u5728\u8a31\u591a\u60c5\u6cc1\u4e0b\uff0cp16\u53ef\u80fd\u70ba\u967d\u6027\u4f46HPV\u6aa2\u6e2c\u537b\u70ba\u9670\u6027\u3002<\/p>\n<p>\u56db\u3001 \u4f9d\u64daWHO Classification of Tumours \u7b2c5\u7248Digestive System Tumours (2019)\uff0c\u5f59\u6574\u6700\u65b0\u75c5\u7406\u7d44\u7e54\u578b\u614b\u7de8\u78bc\u8868(\u8a73\u898b\u901a\u77e5\u6587\u5168\u6587\u4e0b\u8f09\u9644\u4ef6)\uff0c\u9069\u7528\u65bc2019\u8a3a\u65b7\u5e74\u4ee5\u5f8c\u500b\u6848\u3002<\/p>\n<p>[<a href=\"https:\/\/tcr.cph.ntu.edu.31app.tw\/wp-content\/uploads\/2022\/01\/CRS-notice_108009.pdf\">\u764c\u767b\u7b2c108009\u865f\u901a\u77e5\u6587\u5168\u6587\u4e0b\u8f09<\/a>]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e00\u3001 \u672c\u6848\u4fc2\u4f9d\u885b\u751f\u798f\u5229\u90e8\u570b\u6c11\u5065\u5eb7\u7f72\u59d4\u8a17\u300c &hellip; <\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-2157","post","type-post","status-publish","format-standard","hentry","category-lastsnews"],"_links":{"self":[{"href":"https:\/\/twcr.tw\/index.php?rest_route=\/wp\/v2\/posts\/2157","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/twcr.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/twcr.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/twcr.tw\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/twcr.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2157"}],"version-history":[{"count":1,"href":"https:\/\/twcr.tw\/index.php?rest_route=\/wp\/v2\/posts\/2157\/revisions"}],"predecessor-version":[{"id":2173,"href":"https:\/\/twcr.tw\/index.php?rest_route=\/wp\/v2\/posts\/2157\/revisions\/2173"}],"wp:attachment":[{"href":"https:\/\/twcr.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2157"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/twcr.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2157"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/twcr.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2157"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}